The subsequent adverse reactions are already recognized in the course of publish approval usage of VIAGRA. Mainly because these reactions are documented voluntarily from the population of unsure sizing, It's not necessarily constantly achievable to reliably estimate their frequency or establish a causal marriage to drug publicity.
g., creatinine clearance < thirty mL/min), and concomitant usage of erythromycin or powerful CYP3A4 inhibitors, plasma amounts of sildenafil at 24 several hours post dose have already been observed to generally be 3 to eight instances increased than Those people noticed in healthful volunteers. While plasma amounts of sildenafil at 24 several hours post dose are much lower than at peak concentration, it's unfamiliar no matter if nitrates is usually safely co-administered at the moment level [see CONTRAINDICATIONS].
This Evaluation was carried out retrospectively, and was not driven to detect any pre-specified variance in adverse reactions.
VIAGRA might have an affect on the best way other medicines work, and also other medicines might have an affect on the best way VIAGRA works, producing side effects. Especially tell your healthcare service provider if you are taking any of the subsequent:
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sudden eyesight loss in a single or equally eyes.Unexpected vision decline in one or the two eyes might be a signal of a significant eye difficulty termed non-arteritic anterior ischemic optic neuropathy (NAION). Quit getting VIAGRA and contact your Health care service provider straight away When you've got any sudden eyesight decline
VIAGRA has sildenafil, which is similar medicine located in One more drug referred to as REVATIO. REVATIO is utilised to treat a scarce disorder referred to as pulmonary arterial hypertension (PAH).
In scientific studies with healthful volunteers of single doses nearly 800 mg, adverse reactions ended up much like those viewed at decrease doses but incidence prices and severities were being amplified.
Quite a few of such events had been documented to manifest throughout or shortly right after sexual action, and a few have been documented to come about Soon soon after the usage of VIAGRA without having sexual activity. Other people were reported to have occurred hrs to days just after the usage of VIAGRA and sexual exercise. It's not possible to ascertain whether or not these situations are connected straight to VIAGRA, to sexual action, towards the affected individual's underlying cardiovascular disease, to a combination of these elements, or to other elements [see WARNINGS AND Safeguards and Client Information and facts].
In conditions of overdose, conventional supportive steps should be adopted as required. Renal dialysis is not envisioned to speed up clearance as sildenafil is very sure to plasma proteins and It's not necessarily removed from the urine.
Viagra had no effect on saquinavir pharmacokinetics. A more robust CYP3A4 inhibitor for instance ketoconazole or itraconazole can be envisioned to obtain greater effect than that noticed with saquinavir. Population pharmacokinetic info from sufferers in medical trials also indicated a reduction in sildenafil clearance when it had been co-administered with CYP3A4 inhibitors (including ketoconazole, erythromycin, or cimetidine) [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS].
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